EFFECT OF ELECTROCHEMICAL THERAPY ON BREAST CANCERS OF MIDDLE AND LATE STAGES
Dr. Xin Yu-Ling, Dr. Peng Ze-Bing China-Japan Friendship Hospital Beijing 100029, China

ABSTRACT

Electrochemical Therapy (ECT) was applied to one hundred five (105) cases of middle and late stage breast cancer from 1987 to 1990. Among them, 74 cases were primary breast cancer and 31 cases were recurrent cancers after surgical resection. There were 102 female patients and 3 male patients ranging in age from 38 to 91 years; the average age was 52.5 years.

According to the standard 0fTNM staging of breast cancers adopted by the UTCC in 1988, 110 cases were of stage one. Of the 74 primary cases, 16 cases were stage 11; 51 cases were stage III; and 7 cases were stage IV. Thirty one (31) cases of recurrent breast cancer were all stage IV. Pathological examination revealed that of the 74 primary cases, 55 cases were glandular adenocarcinoma, 19 cases were tubular- adenocarcinoma. The 3 1 cases of recurrent cancer were all adenocarcinoma.

According to the UICC standard of 4 grade evaluation of effectiveness, (CR, PR, NC, PD), the short term effective rates of the 105 cases was: CR 35.2%; PR 43.8%; NC 13.4 %; PD 7.6%. The total effective rate was 79.0 % excepting the 11 cases which died in the first year, the five year survival rate of the 94 remaining cases was:

One year survival rate=89.5% (94/105)
Two year survival rate=82.9% (87/105)
Three year survival rate=69.5% (73/105)
Four year survival rate=58.1% (6 1/105)
Five year survival rate=50.5% (53/105)

Therapeutic Method

Using B-type ultrasonography, platinum electrodes were accurately inserted into the cancer and placed all through the tumor mass. Anodes (+ charge) were usually in the center and cathodes (- charge) were at the periphery. The distance between two electrodes was about 2.5 cm. Hence the number of electrodes needed were calculated upon the size of the tumor. The manipulation of the electrodes is simple, easy to handle, safe, and effective. Moreover, recovery time is very rapid. ECT is applicable to various kinds of cancers or tumors. lt may be used safely and effectively with old, weak patients as well as other patients who have no remaining means of treatment. This method is especially suitable for recurrent cancers, and can heal large areas of ulceration. Key words electrochemical! Therapy (ECT), middle and late stage cancer, therapeutic effectiveness.

Electrochemical therapy (ECT) was first used in the treatment of malignant tumors in the early seventies. In 1983, publications of B. Nordenström (1-4) introduced systematically experimental and clinical results of ECT. In 1988, Pekar (5) reported his clinical results in using ECT to treat superficial tumors. In Japan (6), there have been experimental and clinical applications of ECT. Recognising its‘ efficacy as a cancer treatment, it is surprising that ECT has been all but ignored in many parts of the scientific world.

In China, ECT has been studied experimentally and used clinically since 1987. In 1993 a summary of therapeutic results of 2516 cases with ~ kinds of malignant tumors was published (7). The total effective rate ranged between 70 and 80 percent. The results of ECT in treating 105 cases of breast cancer is reported hereof.

1. Clinical Data:
Diagnosis of this group of patients was made by X-ray film, B-type ultrasonography and pathological examination. One hundred and two (102) cases were female and three (3) male. Age ranged from 38 to 91 years; with the average age of 52.2. Among them, 74 cases were primary cancer and 31 cases were e recurrent cancer following surgical resection. Compared with primary cancer, recurrent cancer was difficult to treat and bad an unfavourable prognosis. (Table 1)

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